Each datapoint is a (timestamp,temperature) pair. It sounds like you are assuming that temperature should rise linearly, and you want to estimate the slope (i.e., temperature change divided by time change) of the line.
So, you need to do a linear regression analysis of your data. See the source below for information about linear regression.
Several popular programs (e.g., MATLAB, Microsoft Excel, SPSS, SAS, etc.) can perform the analysis for you. For example, in Microsoft Excel you can have it calculate a "trend line" of your data. This "trend line" represents the result of linear regression analysis.
If you would like to do the calculation yourself, see the "Polynomial fitting" section. In your case, the X matrix has two columns and the alpha vector has two rows. Each point of the y vector has a temperature and the x element of the corresponding row of the X matrix is the timestamp. Solving the equation gives you two parameters, alpha_0 and alpha_1, which represent the temperature intercept and temperature slope of your trend line. You care about the temperature slope.