In math, an "axiom" is anything you assume to be true in order to form the basis for a body of deductions. Depending on which axioms you choose, you can get completely different mathematical results.
In geometry (in high school geometry, anyway) we take Euclid's 5 axioms and go from there. These axioms are:
1. There is a line connecting any 2 points
2. Any line can be extended infinitely
3. There is a unique circle with a given center and radius
4. Any two right angles are equal
5. The parallel postulate
Based on only these 5 statements, we can deduce everything we know about "Euclidean" geometry (for example: sum of a triangle's angles is 180˚, the triangle postulates, and so forth). If we change that 5th statement, the result is a totally different kind of geometry. The systems of geometry that use a different 5th axioms are called "non-Euclidean geometry". These systems of geometry can usually be thought of as the geometry of a warped surface; for example, triangles on the surface of a globe have angles adding to more than 180˚.
The point is, what exactly you choose as your axioms has a significant consequence on the deductions (the "theorems") that result.
So those axioms deal with geometry. The ZFC axioms, on the other hand, deal with set theory. Since we use set theory to count, these axioms essentially tell us what numbers are and how to use them. Based on these axioms, one may deduce everything we know about mathematics as we use it today. The axiom of choice (which corresponds to the C in ZFC) is a little bit like the parallel postulate in that you need it for a lot of things, but a lot of people think it's ugly, so they don't like it and try to get around using it if possible. So, sometimes people talk about using "ZF" instead of "ZFC". There are other sets of axioms that can be used, but these are by far the most popular.
So what's the difference? The axioms talk about different things. Where your "normal" axioms (Euclid's axioms) talk about points and lines, ZFC talks about sets and their subsets and elements.
Hope that helps.